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Journal of Scientific Research and  Studies

Journal of Scientific Research and Studies Vol. 3(6), pp. 119-125, June, 2016

ISSN 2375-8791

Copyright 2016

Author(s) retain the copyright of this article


Full Length Research Paper

Efficacy of renal precursor stem cells in management of chronic kidney disease: a cohort study


Mike Chan1, Michelle Wong2, Mikhail Teppone1 and Dmitry Klokol1*

1Stellar Biomolecular Research, Germany.
2Frontier Cytobiological Therapies International, EU.

*Corresponding author. E-mail:

Accepted 24 June, 2016




In spite of tremendous achievements of modern medical science, chronic kidney disease (CKD) is still considered to be an untreatable pathology. CKD is caused by various etiological factors and is characterized by progressive deterioration of renal function due to loss of functioning nephrons. In absence of definitive treatment, CKD imposes a threat of end-stage renal failure with further necessity of dialysis and kidney transplant. In this article, we present a combined data on application of stem cell therapy in patients with CKD stages 3a and 3b. The influence of precursor cell implantation on parameters of renal profile is studied in a group of 23 patients with CKD stage 3a and 3b. Results of stem cell implantation were evaluated 6 months and 1 year after the procedure. 78.5% of patients with CKD stage 3a had improvement of their serum creatinine level and GFR. In the group of patients with CKD stage 3b, 66.7% had improvement of parameters of renal function test and downstaging of CKD. Fetal precursor cell application in management of CKD is a promising therapeutic modality and requires further detailed analysis and continued clinical trials.

Key words: Kidney, renal failure, precursor stem cell, xenotransplantation, kidney repair.

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Vol. 3 Issue 6

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